Urticaria (hives) is a common mast cell–mediated dermatosis characterized by development of pruritic erythematous superficial plaques, angioedema or both. This CME includes a detailed discussion on prevalence, different types, diagnosis and differential diagnosis of urticaria. It will not only present the different approaches towards management of urticaria but will also give us an insight on the current and future options available as pharmacological treatment.